Total synthesis of eurypamides, marine cyclic-isodityrosines from the Palauan sponge Microciona eurypa |
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| Authors: | Miyuki Ito |
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| Affiliation: | Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan |
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| Abstract: | Total synthesis of eurypamides A, B, and D, 1, 2, and 4, has been successfully accomplished. The Tl(NO3)3 (TTN) oxidation of the halogenated bisphenols, 14a, 14b, 24, and 43, effected regio-controlled cyclization to provide the corresponding diaryl ethers, 15a, 15b, 25, and 46. This investigation revealed a structural revision of eurypamide A as to possess (2″S,3″R,4″S)-configuration (47), along with the spectral data of pure 2 and 4, which were previously characterized in a mixture. |
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| Keywords: | Eurypamides Isodityrosine smallcaps" >l-Threonine |
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