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Enzymatic synthesis of optically active α-chloro-δ-hydroxy-β-ketoalkanephosphonates and reactions thereof |
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| Authors: | Chengfu Xu |
| Institution: | Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Lu, Shanghai 200032, China. |
| Abstract: | A novel and enzymatic approach to α-chloro-δ-hydroxy-β-ketoalkanephosphonates was developed via enantioselective CALB-catalyzed acetylation and CRL-catalyzed hydrolysis. The resultant optically active compounds provide, via Horner-Wadsworth-Emmons (HWE) reaction, chiral α,β-unsaturated ketones that are building block with potential application in organic synthesis. |
| Keywords: | Horner-Wadsworth-Emmons (HWE) reaction α-Chloro-δ-hydroxy-β-ketoalkanephosphonates Candia Antartic lipase B (CALB) Crude Candia Rugosa lipase (CRL) Acetylation Hydrolysis α β-Unsaturated ketones |
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