A selective reductive amination of aldehydes by the use of Hantzsch dihydropyridines as reductant |
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| Authors: | Takashi Itoh |
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| Institution: | School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan |
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| Abstract: | Direct reductive amination of an aldehyde was carried out using a Hantzsch dihydropyridine as the reductant in the presence of a catalytic amount of scandium triflate. The reaction was highly selective towards aldehydes over ketones, and other reducible functional groups did not affect the reaction. |
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| Keywords: | Aldehyde Ketone Direct reductive amination Imine Hantzsch dihydropyridine Scandium (III) triflate Lewis acid |
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