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Five new derivatives of nonactic and homo-nonactic acids from Streptomyces globisporus
Affiliation:a Institute of Microbiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague, Czech Republic
b Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem 91120, Israel
Abstract:In addition to the known compounds of the type of nonactic and homononactic acids and their lactones, dilactones and tetralactones, five new compounds, namely homononactyl-nonactoate, a dilactone consisting of nonactic and homononactic acids and three cyclic trimers with nonactic and homononactic acids, were isolated from a strain of Streptomyces globisporus. Their structures, including the absolute configurations of the hydroxyl and methyl groups, were determined by extensive spectroscopic techniques such as UV, IR, MS, 1D and 2D NMR.
Keywords:Streptomyces globisporus   Nonactic acid   Homo-nonactic acid   Dilactone   Trilactones
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