Synthesis of new 6-substituted purinyl-5′-nor-1′-homocarbanucleosides based on indanol |
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| Authors: | Franco Ferná ndez,Melvin Morales,Olga Caamañ o |
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| Affiliation: | a Departamento de Química Orgánica, Facultade de Farmacia, Universidade de Santiago de Compostela, E-15782 Santiago de Compostela, Spain
b Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium |
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| Abstract: | A series of new 6-substituted purinyl-5′-nor-1′-homocarbanucleosides based on indanol were synthesized from (±)-cis-3-hydroxymethyl-1-indanol, an appropriately functionalized derivative of which was reacted with 6-chloropurine in the presence of NaH and 18-crown-6 ether to prepare a key intermediate that gave access to the target molecules, purinylcarbanucleosides in which position 6 is occupied by a chloro, hydroxy, methoxy, amino or substituted phenyl group. |
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| Keywords: | Synthesis Antiviral agents Antineoplastic agents Indan carbanucleosides Suzuki-Miyaura cross-coupling reaction |
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