|
|||||
|
|
A biocatalytic route to enantioenriched, sulfanyl aldol products |
|
| Authors: | C. Baker-Glenn V. Gouverneur |
| Affiliation: | a Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK b GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, UK |
| Abstract: | The aldol products derived from sulfur- or selenium containing acceptors were prepared by kinetic resolution in the presence of antibody 84G3 with enantiomeric excesses ranging from 56 to 70%. Much higher level of enantioselectivity was obtained (enantiomeric excesses all superior to 96%) for sulfanyl aldol products derived from thiomethoxyacetone with three different acceptors. |
| Keywords: | Catalytic antibodies Aldol additon Sulfur |
| 本文献已被 ScienceDirect 等数据库收录！ | |