Palladium-catalyzed couplings to nucleophilic heteroarenes: the total synthesis of (−)-frondosin B |
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| Authors: | Chambers C. Hughes |
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| Affiliation: | Department of Chemistry, Center for New Directions in Organic Synthesis, University of California, 419 Latimer Hall, Berkeley, CA 94720, USA |
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| Abstract: | The total synthesis of (−)-frondosin B, the enantiomer of naturally-occuring (+)-frondosin B, is described, wherein a palladium-catalyzed cyclization is used to establish the tetracyclic ring system of the natural product. |
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| Keywords: | Frondosin Heck reaction Palladium catalysis Total synthesis |
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