三种浙产特色药材炮制前后微量元素与重金属的含量研究

用微波消解-电感耦合等离子体质谱法(ICP-MS)同时测定了3种浙产特色药材炮制前后Mn,Fe,Cu,Zn,Cr,As,Cd,Pb的含量。该方法的加样回收率在95.2%～106.3%之间,相对标准偏差RSD在0.69%～2.34%之间。试验结果显示,3种药材炮制前后对人体有益的微量元素Mn,Fe,Zn的含量均较高;而有害重金属元素Cu,Cd,Cr,Pb,As的含量均低于《中国药典》的限量标准,炮制加工均使其中的微量元素及重金属含量有所变化,不同的炮制方法在个别元素含量上存在差异。炮制后除Pb的含量明显下降,Cu,As,Cd基本不变外,其他元素的含量均有不同程度的增加,这种差异可能与药材的炮制方法有关。该测定结果为进一步探讨3种浙产特色药材的炮制方法与其功效的相关性提供了科学依据。

Research on the Content of Trace Elements and Heavy Metals in the Three Kinds of Zhejiang Specific Medicinal Materials before and after Processing

By establishing the ICP-MS determining method,we determined the contents of Mn,Fe,Cu,Zn,Cf,As,Cd and Pb in the three kinds of ZheJfang specific medicinal materials before and after processing them.The recovery ratio with standard addition of the method is between 95.2% and 106.3,and the relative standard deviation between 0.69% and 2.34%.The results of the experiment show that the contents of useful metals Mn,Fe,Cu and Zn are fairly high both before and after processing,while the contents of harmful heavy metals Cd,Cr,Pb and As are all lower than the limited quantity in the standard of Chinese Pharmacopoeia.After processing,there seen～to be some content changes in the trace elements and heavy metals.Different content changes depend on different processing methods.After processing,except the notable decrease in Pb,the contents of Cu,As and CA are almost constant,while the contents of other elements are nearly alIincreased.The result seerfl8 to be related with the methods of processing.This experimental result provides us with new scientific foundation for the further research on the relationship between different processing methods and different efficacy of the three specific Zhejiang medicinal materials.