Development of a voltammetric sensor for diospyrin determination in nanomolar concentrations |
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Authors: | de Oliveira Costa Cicero Miranda Paulo R B Hazra Banasri Das Sarma Madhushree de Cássia Silva Luz Rita Kubota Lauro Tatsuo Goulart Marília Oliveira Fonseca |
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Institution: | a Department of Chemistry, CCEN, Federal University of Alagoas, 57072-970 Maceió, AL, Brazil b Department of Pharmaceutical Technology, Jadavpur University, 700032 Calcutta, India c Institute of Chemistry, UNICAMP, P.O. Box 6154, 13084-971 Campinas, SP, Brazil |
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Abstract: | A sensor based on glassy carbon (GC) electrode modified with cobalt tetrasulfonated phthalocyanine (CoTSPc) and a poly-l-lysine (PLL) film is proposed for diospyrin determination in nanomolar concentrations with differential pulse voltammetry (DPV) technique. The modified electrode showed excellent catalytic activity presenting much higher peak currents than those measured on a bare GC electrode. Linear response range, sensitivity and limit of detection (LOD) were of 1-120 nmol l−1, 220.46 nA l nmol−1 cm−2 and 0.3 nmol l−1, respectively. The repeatability of the proposed sensor, evaluated in term of relative standard deviation (R.S.D.), was measured as 4.4% for 10 experiments in 50 μmol l−1 diospyrin samples. The developed sensor was applied for the determination of diospyrin in the crude extracts of the stem-bark of Diospyros montana Roxb. and the average recovery for these samples was 101.9 (±3.1)%. |
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Keywords: | Diospyrin Cobalt tetrasulfonated phthalocyanine l-lysine" target="_blank">Poly-l-lysine |
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