Mixed micelles of tetradecyltrimethylammonium bromide and chlorhexidine digluconate in aqueous solutions of isopropyl alcohol |
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| Authors: | D Attwood H K Patel V Mosquera |
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| Institution: | (1) Present address: Department of Pharmacy, University of Manchester, Manchester, UK;(2) Departmento de Fisica de la Materia Condensada, Facultad de Fisica, Universidad de Santiago de Compostela, Spain |
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| Abstract: | The influence of isopropyl alcohol (IPA) on the size and composition of the mixed micelles in mixtures of tetradecyltrimethylammonium bromide (TTAB) and chlorhexidine digluconate (CG) has been determined as a function of the composition of the systems. The addition of 0.5 M and 1.0 M IPA had little significant effect on the composition of the mixed micelles as determined both by analysis of critical micelle concentration (CMC) data using a theoretical treatment based on excess thermodynamic quantities and by an empirical treatment of conductivity data. Static and quasielastic light scattering measurements showed a progressive decrease of the aggregation number and hydrodynamic radius of TTAB micelles on addition of IPA, but minimal changes in the properties of the small CG aggregates. The results show that the micellar weight in the TTAB/CG/IPA solutions is determined by the ratio of the surfactants in the system and for each TTAB/CG ratio decreases on addition of IPA. |
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| Keywords: | Mixed micelles tetradecyltrimethylammonium bromide micelles chlorhexidinedigluconate alcohol effect on mixed micelles critical micelle concentrations |
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