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| 微量热法研究硒对大肠杆菌生长代谢的作用 | |
| 引用本文： | 李曦,刘义,吴军,赵儒铭,屈松生. 微量热法研究硒对大肠杆菌生长代谢的作用[J]. 物理化学学报, 2000, 16(6): 568-572. DOI: 10.3866/PKU.WHXB20000618 |
| 作者姓名： | 李曦 刘义 吴军 赵儒铭 屈松生 |
| 作者单位： | College of Chemistry and Environment Science,College of Life Science,Wuhan University,Wuhan 430072,School of Material Science and Technology,Wuhan University of Technology,Wuhan 430070,Department of Chemistry,Hubei Three Gorge University,Hubei 443000 |
| 基金项目： | 国家自然科学基金，湖北省自然科学基金，武汉大学青年学术骨干专项基金 |
| 摘 要： | 硒 是生物必需的微量元素之一．自从１９７３年Ｒｏｔｒｕｃｋ报导了第一个硒酶———红细胞谷胱甘肽过氧化物酶［１］,硒在生命科学中的研究取得了令人瞩目的进展．继红细胞谷胱甘肽过氧化物酶之后 ,从哺乳动物中还发现硒为多种酶所必需 ;此外 ,在不同的动物组织中一系列含硒蛋白被分离和鉴别．随着分子生物学技术的发展和硒在生物化学中的应用 ,人们对硒的生物化学本质有了更加深刻的认识 ,其中 ,遗传基因硒代半胱氨酸密码子ＵＧＡ的发现使硒的生物化学研究进入了一个新的阶段．与此同时 ,小分子有机硒化合物Ｅｂｓｅｌｅｎ生物活性的发现… |
| 关 键 词： | 微量热法 含硒络合物 大肠杆菌 生长代谢 |
| 收稿时间： | 1999-10-14 |
| 修稿时间： | 2000-01-17 |
Microcalorimetric Study of the Action of Selenium-containing Complexeson Growth Metabolism of Escherichia coli |
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| Li Xi, Liu Yi Wu Jun Zhao Ruming, Qu Songsheng. Microcalorimetric Study of the Action of Selenium-containing Complexeson Growth Metabolism of Escherichia coli[J]. Acta Physico-Chimica Sinica, 2000, 16(6): 568-572. DOI: 10.3866/PKU.WHXB20000618 | |
| Authors: | Li Xi Liu Yi Wu Jun Zhao Ruming Qu Songsheng |
| Affiliation: | College of Chemistry and Environment Science,College of Life Science,Wuhan University,Wuhan 430072|School of Material Science and Technology,Wuhan University of Technology,Wuhan 430070|Department of Chemistry,Hubei Three Gorge University,Hubei 443000 |
| Abstract: | The thermokinetic characteristics of the actions of selenium containing complexes on the growth metabolism of Escherichia coli were studied by means of microcalorimetry. It was found that at low concentration of Na2SeO3 and N, N′-methylene bisselenomorpholine promoting action on the growth of Escherichia coli, and at high concentration inhibiting action were observed but selenomorpholine had only inhibiting action. Considering both the half inhibition concentration(Ic50) and the rate constant (k), the inhibiting activity of selenium containing complexes studied is in the series of N, N′-methylene bisselenomorpholine > Na2SeO3 and selenomorpholine. |
| Keywords: | Microcalorimetry Selenium containing complexes Escherichia coli Growth metabolism |
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