Preparation and characterization of a novel pH-sensitive ion exchange resin |
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| Authors: | Liu Hongfei Zhang Shu Nie Shufang Zhao Xin Sun Xiyang Yang Xingang Pan Weisan |
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| Affiliation: | Department of Pharmaceutics, Shen yang Pharmaceutical University, Shen yang 110016, People's Republic of China. liuhongfei1979@sohu.com |
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| Abstract: | Methylacrylic acid/styrene cross-linked with divinylbenzene is a novel pH-sensitive ion exchange resin. Microspheres of this resin were characterized by Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). The microspheres showed a pulsatile swelling behavior when the pH of the media changed. The pH-sensitive microspheres were loaded with salbutamol sulfate and the drug-release characteristics were studied under both simulated gastric and intestinal pH conditions. The results obtained showed that the drug release also depended on the pH of the release media. |
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