The relationship between self-organization and membrane effects of aqueous dispersion systems of the thyroliberin oligopeptide |
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| Authors: | A. I. Konovalov I. S. Ryzhkina N. P. Pal’mina E. L. Mal’tseva S. Yu. Sergeeva L. I. Murtazina O. A. Salakhutdinova M. D. Shevelev V. E. Zhernovkov |
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| Affiliation: | 1.Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center,Russian Academy of Sciences,Kazan,Russia;2.Emanuel Institute of Biochemical Physics,Russian Academy of Sciences,Moscow,Russia;3.Kazan (Volga Region) Federal University,Kazan,Russia;4.Doklady Akademii Nauk,Moscow,Russia |
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| Abstract: | The relationship between rearrangement of the dispersed phase inducing considerable changes in the pH and nonmonotonic concentration dependences of membrane effects in aqueous systems of the endogenous regulatory peptide, thyroliberin (thyrotropin-releasing hormone), in 10–3–10–16 mol/L concentration range was demonstrated for the first time. The membrane structure modification in the 10–13–10–16 mol/L range was found to be due to accumulation of nanoassociates, while the oppositely directed pronounced structural changes in the 10–6–10–12 mol/L range may be associated with the coexistence and rearrangement of dispersed phases of various nature (domains and associates) whose action on membrane lipid components is regulated in this concentration range by the correlated changes in the dispersed phase parameters and pH. |
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