A modified procedure for synthesis of the side chain of ceftazidime-activated thioester |
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| Authors: | Lei Li Guangyuan Wang Shanshan Wei Xilong Yan Ligong Chen |
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| Affiliation: | 1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People’s Republic of China
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| Abstract: | A modified procedure for synthesis of the side chain of ceftazidime-activated thioester has been established. This key intermediate of ceftazidime was obtained by a more eco-friendly process than conventional methods, and the yield was much higher (up to 92.4 %). It was found that different organic bases (triethylamine or pyridine) used in this reaction had different effects. The reaction conditions were also optimized to make the route more competitive and suitable for large-scale industrial production. |
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