Preparation of composite with silica-coated nanoparticles of iron oxide spinels for applications based on magnetically induced hyperthermia |
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Authors: | Angela L Andrade José D Fabris Márcio C Pereira Rosana Z Domingues José D Ardisson |
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Institution: | 1. Department of Chemistry, Federal University of Ouro Preto (UFOP), 35400-000, Ouro Preto, Minas Gerais, Brazil 2. Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), 39100-000, Diamantina, Minas Gerais, Brazil 3. Institute of Science, Engineering and Technology, Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), 39803-371, Teófilo Otoni, Minas Gerais, Brazil 4. Department of Chemistry, Federal University of Minas Gerais (UFMG), 31270-901, Belo Horizonte, Minas Gerais, Brazil 5. Laboratory of Applied Physics, Development Center of Nuclear Technology (CNEN/CDTN), 31270-901, Belo Horizonte, Minas Gerais, Brazil
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Abstract: | It is reported a novel method to prepare magnetic core (iron oxide spinels)–shell (silica) composites containing well-dispersed magnetic nanoparticles in aqueous solution. The synthetic process consists of two steps. In a first step, iron oxide nanoparticles obtained through co-precipitation are dispersed in an aqueous solution containing tetramethylammonium hydroxide; in a second step, particles of this sample are coated with silica, through hydrolyzation of tetraethyl orthosilicate. The intrinsic atomic structure and essential properties of the core–shell system were assessed with powder X-ray diffraction, Fourier transform infrared spectrometry, Mössbauer spectroscopy and transmission electron microscopy. The heat released by this ferrofluid under an AC-generated magnetic field was evaluated by following the temperature evolution under increasing magnetic field strengths. Results strongly indicate that this ferrofluid based on silica-coated iron oxide spinels is technologically a very promising material to be used in medical practices, in oncology. |
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