Guapsidial A and Guadials B and C: Three New Meroterpenoids with Unusual Skeletons from the Leaves of Psidium guajava |
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| Authors: | Yu‐Qing Jian Dr Xiao‐Jun Huang Dr Dong‐Mei Zhang Prof?Dr Ren‐Wang Jiang Min‐Feng Chen Dr Bing‐Xin Zhao Prof?Dr Ying Wang Prof?Dr Wen‐Cai Ye |
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| Institution: | 1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632 (P.R. China), Fax: (+86)?20‐8522‐1559;2. JNU‐HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University, Guangzhou 510632 (P.R. China) |
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| Abstract: | A novel sesquiterpene‐based Psidium meroterpenoid, possessing an unusual coupling pattern, and two new monoterpene‐based meroterpenoids with unprecedented skeletons were isolated from the leaves of Psidium guajava. Their structures and absolute configurations were elucidated by spectroscopic, X‐ray diffraction, and computational methods. The plausible biosynthetic pathway of these meroterpenoids as well as their cytotoxicities toward HepG2 and HepG2/ADM cells were also discussed. |
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| Keywords: | biogenetic pathways cytotoxicity meroterpenoids natural products structure elucidation |
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