| EFFECTS OF MONOCLONAL ANTIBODY ANTIEGF RECEPTOR ON HUMAN NASOPHARYNGEAL CARCINOMA CELL AND OTHER TUMOR CELLS |
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| 作者姓名： | 管恩南 周廷冲 王晋海 陈勇 孙英勋 黄培根 唐蔚萍 赵明伦 |
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| 作者单位： | Institute of Basic Medical Sciences，Academy of Military Medical Sciences，CPLA，Beijing 100850，PRC，Institute of Basic Medical Sciences，Academy of Military Medical Sciences，CPLA，Beijing 100850，PRC，Institute of Basic Medical Sciences，Academy of Military Medical Sciences，CPLA，Beijing 100850，PRC，Institute of Basic Medical Sciences，Academy of Military Medical Sciences，CPLA，Beijing 100850，PRC，Institute of Basic Medical Sciences，Academy of Military Medical Sciences，CPLA，Beijing 100850，PRC，Department of Cancer Research，Zhanjiang Medical College，ZhanJiang 524023，PRC，Department of Cancer Research，Zhanjiang Medical College，ZhanJiang 524023，PRC，Department of Cancer Research，Zhanjiang Medical College，ZhanJiang 524023，PRC |
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| 摘 要： | Three anti-EGF receptor MoAbs were used in these studies. Administration of MoAbs 3 and 176 inhibited tumor formation in nude mice by CNE-2, a poorly differentiated nasopharyngeal carcinoma cell line and A431, an epidermoid carcinoma cell line. When the same MoAbs were used in treatment against HeLa, a cervical carcinoma, tumor growth was not affected. The number of EGF receptors and apparent dissociation constants for ~(125)I-EGF on CNE-2 and A431 was 1.3×10~(?)/cell (Kd 7.7×10~(-8)mol/L) and 1.4×10~6/cell(Kd 2.4×10~(-9)mol/L), respectively. Both MoAbs 3 and 176, capable of competing with EGF for receptor binding, showed significant tumor growth inhibition. MoAb 101 was incapable of blocking the binding of EGF to its receptor, and not as effective as MoAbs 3 and 176 in tumor growth inhibition. Our observation is that the MoAb anti-EGF receptor is cytostatic rather than cytocidal, in vitro against CNE-2 and A431.
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EFFECTS OF MONOCLONAL ANTIBODY ANTIEGF RECEPTOR ON HUMAN NASOPHARYNGEAL CARCINOMA CELL AND OTHER TUMOR CELLS |
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| GUAN EN-NAN ZHOU TING-CHONG WANG JIN-HAI CHEN YONG SUN YING-XUN.EFFECTS OF MONOCLONAL ANTIBODY ANTIEGF RECEPTOR ON HUMAN NASOPHARYNGEAL CARCINOMA CELL AND OTHER TUMOR CELLS[J].Science in China(Chemistry),1990(11). |
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| Authors: | GUAN EN-NAN ZHOU TING-CHONG WANG JIN-HAI CHEN YONG SUN YING-XUN |
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| Abstract: | |
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| Keywords: | nasopharyngeal carcinoma EGF receptor monoelonal antibody CNE-2 A431 |
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