Synthesis and aggregation behavior of <Emphasis Type="Italic">N</Emphasis>-succinyl-o-carboxymethylchitosan in aqueous solutions |
| |
Authors: | Aiping Zhu Lanhua Yuan Yan Lu |
| |
Institution: | (1) College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, People’s Republic of China |
| |
Abstract: | A simple and novel method was developed to successfully synthesize N-succinyl-O-carboxymethylchitosan (NSOCMCS) using N-acylation of chitosan with succinic anhydride. The NSOCMCS structure was characterized by Fourier transform infrared and
1H nuclear magnetic resonance. The aggregation behaviors of NSOCMCS were studied using fluorescence spectroscopy, dynamic light
scattering, and atomic force microscopy techniques. The critical aggregation concentration of NSOCMCS in water was determined
to be 0.2–0.3 mg/ml. The apparent hydrodynamic radium of an NSOCMCS aggregate was dependent on the concentration. The aggregates
demonstrated a much swollen association conformation in aqueous solution. The possible aggregation mechanisms for the NSOCMCS
in water are discussed. Moreover, a driving force to form an open aggregation morphology was revealed in this study. Aggregation
behaviors are important physicochemical properties of NSOCMCS, which impact the potential application in the biomedical field. |
| |
Keywords: | N-succinyl-O-carboxymethylchitosan Preparation Aggregation behaviors Characterization |
本文献已被 SpringerLink 等数据库收录! |