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A novel MCR of isocyanates, aldehydes, and dienophiles
Authors:Strübing Dirk  Neumann Helfried  Hübner Sandra  Klaus Stefan  Beller Matthias
Affiliation:Leibniz-Institut für Organische Katalyse an der Universit?t Rostock e.V., Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
Abstract:[reaction: see text] A novel one-pot procedure for the three-component coupling reaction of isocyanates, aldehydes, and dienophiles (IAD reaction) has been developed. Condensation of isocyanates and aldehydes and subsequent Diels-Alder reactions with electron-deficient dienophiles furnishes endo-selective amino-substituted cyclohexenes in good yield.
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