A novel MCR of isocyanates, aldehydes, and dienophiles |
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Authors: | Strübing Dirk Neumann Helfried Hübner Sandra Klaus Stefan Beller Matthias |
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Affiliation: | Leibniz-Institut für Organische Katalyse an der Universit?t Rostock e.V., Albert-Einstein-Strasse 29a, 18059 Rostock, Germany. |
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Abstract: | [reaction: see text] A novel one-pot procedure for the three-component coupling reaction of isocyanates, aldehydes, and dienophiles (IAD reaction) has been developed. Condensation of isocyanates and aldehydes and subsequent Diels-Alder reactions with electron-deficient dienophiles furnishes endo-selective amino-substituted cyclohexenes in good yield. |
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