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| 利用串联的氮杂Wittig反应方便合成3-[取代吡啶(噻唑)甲基]-1,2,3-三唑[4,5-d]嘧啶-7-酮及其除草活性 | |
| 引用本文： | 肖琳霞,石德清. 利用串联的氮杂Wittig反应方便合成3-[取代吡啶(噻唑)甲基]-1,2,3-三唑[4,5-d]嘧啶-7-酮及其除草活性[J]. 有机化学, 2010, 30(1): 85-91 |
| 作者姓名： | 肖琳霞 石德清 |
| 作者单位： | 华中师范大学化学学院,农药与化学生物学教育部重点实验室,武汉,430079 |
| 基金项目： | 国家自然科学基金，湖北自然科学基金 |
| 摘 要： | 用串联的氮杂Wittig关环反应合成了一系列3-[取代吡啶(嘧啶)甲基]-1,2,3-三唑[4,5-d]嘧啶-7-酮.膦亚胺4和芳基异氰酸酯发生氮杂Wittig反应生成碳二亚胺5,继而在乙醇钠催化下与各种脂肪伯胺关环,以较好的收率得到目标产物7.初步生物活性测试结果表明:该系列部分化合物在100 mg/L的浓度下对双子叶植物油菜显示出较好的除草活性. |
| 关 键 词： | 取代吡啶 噻唑 1,2,3-三唑[4,5-d]嘧啶-7-酮 氮杂Wittig反应 除草活性 |
| 收稿时间： | 2009-05-09 |
| 修稿时间： | 2009-07-06 |
A Convenient Synthesis of 3-[Substituted pyridyl(or thiazolyl)methyl]-1,2,3-triazolo[4,5-d]pyrimidin-7-one via the Tandem Aza-Wittig Reaction and Their Herbicidal Activity |
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| Xiao Linxia,Shi Deqing. A Convenient Synthesis of 3-[Substituted pyridyl(or thiazolyl)methyl]-1,2,3-triazolo[4,5-d]pyrimidin-7-one via the Tandem Aza-Wittig Reaction and Their Herbicidal Activity[J]. Chinese Journal of Organic Chemistry, 2010, 30(1): 85-91 | |
| Authors: | Xiao Linxia Shi Deqing |
| Affiliation: | (Key Laboratory of Pesticide and Chemical Biology of Ministry of Education，College of Chemistry， Central China Normal University，Wuhan 430079) |
| Abstract: | A series of 3-[substituted pyridyl(or thiazolyl)methyl]-1,2,3-triazolo[4,5-d]pyfimidin-7-ones were synthesized via the tandem Aza-Wittig reaction annulation.The carbodiimides 5,obtained from the aza-Wittig reaction of iminophosphorane 4 with aromatic isocyanates,reacted with a variety of primary aliphatic amines in the presence of a catalytic amount of EtONa to give the target compounds 7 in moderate yields.The preliminary bioassay indicated that some of the target compounds displayed good herbicidal activity againstBrassica campestris L at the dosage of 100 mg/L. |
| Keywords: | substituted pyridine thiazole 1,2,3-triazolo[4,5-d]pyrimidin-7-one aza-Wittig reaction herbicidal activity |
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