An efficient synthesis of enantiomerically pure (R)-pipecolic acid, (S)-proline, and their N-alkylated derivatives |
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| Authors: | Fadel Antoine Lahrache Nabil |
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| Affiliation: | Laboratoire de Synthèse Organique et Méthodologie, CNRS, UMR 8182, Institut de Chimie Moléculaire et des Matériaux d'Orsay, Batiment 420, Univ Paris-Sud, 91405 Orsay, France. antfadel@icmo.u-psud.fr |
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| Abstract: | Enantiomerically pure (R)-(+)-pipecolic acid was synthesized in four steps and 42% overall yield starting from dihydropyran and (R)-alpha-methylbenzylamine. A general short strategy is also described for preparing (S)-proline (47.5% overall yield) and derivatives. |
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