心脏中的螺旋波和时空混沌的抑制研究

以Luo-Rudy相I心脏模型为基础,研究心脏中螺旋波和时空混沌的控制,提出了两种控制方法: (Ⅰ)通过交替改变细胞外钾离子浓度来产生平面波,再利用弱外电场辅助平面波抑制螺旋波和时空混沌; (Ⅱ)先提高细胞外钾离子浓度,然后利用外电场激发波的方式产生平面波,再用平面波去抑制螺旋波和时空混沌. 研究结果表明,只要适当选择控制参数,这两种方法都能够有效抑制螺旋波和时空混沌. 当心肌出现局部缺血时,在心肌缺血处就会出现高的细胞外钾离子浓度,在这种情况下, 可以采用电场发射波的方法来抑制心脏中的螺旋波和时空混沌.对这些控制方法的优点和控制机制做了解释.

Suppressions of spiral waves and spatiotemporal chaos in cardiac tissue

Suppressions of spiral waves and spatiotemporal chaos in cardiac tissue are investigated by using the Luo-Rudy phase I model. Two control methods are proposed.(Ⅰ) A planar wave is generated by alternately changing the extracellular potassium ion concentration, and then a weak external electric field is used to help plane wave to suppress spiral waves and spatiotemporal chaos.(Ⅱ) The extracellular potassium ion concentration is first enhanced.Planar waves are then generated by the wave emission induced by an external electric field.We use the planar waves to suppress the spiral waves and spatiotemporal chaos.The results show that the control methods can effectively suppress spiral waves and spatiotemporal chaos when relevant parameters are appropriately chosen.When regional myocardial ischemia occurs,high extracellular potassium ion concentration will appear where myocardial ischemia occurs. The methods of wave emission can be used to suppress spiral waves and spatiotemporal chaos in heart in this case.The advantages and mechanism of the control methods are explained.