吡嗪双甾体的化学

吡嗪双甾体，包括从海洋寄生虫Cephalodiscusglichristi体内分离得到Cephalostatins和从海洋生物Ritterellatokioka体内分离得到的Ritterazines以及它们的人工合成类似物，是一类结构复杂的甾体－生物碱杂化体，它们不仅具有独特的化学结构，而且表现出极其显著的抗肿瘤活性。自从1988年，第一个吡嗪双甾体cephalostation1被报道后，至今许多新的天然的或非天然的吡嗪双甾体出现在各种科学期刊中。本文重点综述了1988年至1998年期间有关吡嗪双甾体结构与合成方面的研究情况。

The chemistry of pyrazino-bis-steroids

Pyrazino - bis - steroids, including cephalostatins isolated from the marine worm Cephalodiscus glichristi, ritterazines isolated from the tunicate Ritterella tokioka as well as their artificial analogues, are a group of complex steroid - alkaloid hybrids. These compounds not only possess the unique structural characteristics, but also show potent anfitumor biological activities. Since the first natural pyrazino - bis - steroids, cephalostatin 1 was reported in 1988, many new natural and unnatural analogues successively have appeared in the scientific literature. This review deals with the structure and synthesis of pyrazino - bis - steroids and covers the literature published in 1988 to 1998.