A novel stereocontrolled synthesis of 1,2-trans cyclopropyl ketones via suzuki-type coupling of acid chlorides with cyclopropylboronic acids |
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| Authors: | Chen H Deng M Z |
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| Institution: | Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Academia Sinica, China. |
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| Abstract: | reaction: see text] The palladium-catalyzed cross-coupling reaction of cyclopropylboronic acids with acyl chlorides was achieved by the combination of Ag(2)O and K(2)CO(3) as the base. Highly enantiomerically enriched cyclopropyl ketones (ee >90%) were also obtained by the reaction of corresponding chiral cyclopropylboronic acids. |
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