Biodegradable microspheres with poly(<Emphasis Type="Italic">N</Emphasis>-isopropylacrylamide) Enriched surface: Thermo-responsibility,biodegradation and drug release |
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| Authors: | Yin Yuan Pei-jian Sun Xu-dong Shi Zhi-hua Gan Fo-song Wang |
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| Institution: | 1. CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;2. The Key Laboratory of Tobacco Chemistry, Zhengzhou Tobacco Research Institute, China National Tobacco Corporation, Zhengzhou 450001, China;3. CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China;State Key Laboratory of Organic-inorganic Composites, Beijing Laboratory of Biomedical Materials,College of Life Sciences and Technology, Beijing 100029, China |
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| Abstract: | Microspheres with thermo-responsible surface were fabricated by PCL-b-PEO-b-PNIPAM triblock copolymers. Thermo-responsible morphological changes of PCL-b-PEO-b-PNIPAM microspheres immersed in aqueous solution at temperatures above the LCST (e.g. 37 °C) were observed from porous surface structure to compact surface layer. Enzymatic degradation and in vitro drug release results showed that the thermo-responsible surface layer greatly influenced the degradation of microspheres as well as the drug release behavior from microspheres. With the copolymerization of PNIPAM block into PCL-b-PEO copolymers, the drug release could be well regulated by changing temperatures and microspheres composition, which revealed the great potentials of microspheres with thermo-responsible surface for controlled drug release. |
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| Keywords: | Microspheres Poly(N-isopropylacrylamide) Thermo-sensitive Biodegradation |
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