New steroidal alkaloids from Fritillaria imperialis and their cholinesterase inhibiting activities |
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| Authors: | Atta-Ur-Rahman Akhtar Muhammad Nadeem Choudhary Muhammad Iqbal Tsuda Yoshisuke Sener Bilge Khalid Assad Parvez Masood |
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| Affiliation: | H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan. |
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| Abstract: | Two new cevanine steroidal alkaloids, impericine (1) and forticine (2) along with known bases delavine (3), persicanidine A (4), and imperialine (5) were isolated from the bulbs of Fritillaria imperialis. The structures of impericine (1) [(20R,22S,25S)-5alpha-cevanin-23-ene-3beta,6beta,16beta-triol] and forticine (2) [(20S,22S,25S)-5alpha-cevanine-3beta,6beta-diol] were determined with the help of spectroscopic studies. These steroidal bases showed anti-acetylcholinesterase and anti-butyrylcholinesterase inhibitory activity. |
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