| 近红外到近红外Mn2+掺杂NaYF4:Yb3+/Tm3+纳米粒子的制备及其生物成像 |
| |
| 引用本文： | 罗阳,廖正芳,张伟,左芳.近红外到近红外Mn2+掺杂NaYF4:Yb3+/Tm3+纳米粒子的制备及其生物成像[J].发光学报,2018,39(10):1371-1377. |
| |
| 作者姓名： | 罗阳 廖正芳 张伟 左芳 |
| |
| 作者单位： | 西南民族大学 化学与环境保护工程学院, 四川 成都 610041 |
| |
| 基金项目： | 国家自然科学基金（51273220）；中央高校基础科研项目（2017NZYQN17）资助 |
| |
| 摘 要： | 在反应温度为200℃、反应时间为8 h的温和条件下，采用水热法合成了近红外到近红外的Mn2+掺杂NaYF4:Yb3+/Tm3+上转换荧光纳米粒子，再以两亲性聚合物C18PMH-mPEG作为亲水性配体修饰到上转换荧光纳米粒子表面，得到具有水溶性的上转换荧光纳米粒子。然后在980 nm近红外光源激发下，测量了上转换荧光纳米粒子的荧光发射光谱，在（800±10） nm附近，观察到了较强的单近红外光发射（3H4→3H6）。对样品进行细胞毒性实验，结果表明制得的水溶性Mn2+掺杂NaYF4:Yb3+/Tm3+纳米粒子具有良好的生物相容性。并进一步在小鼠体内进行了近红外成像，表明其在生物成像领域将会具有一定的应用前景。
|
| 关 键 词： | 水热法 Yb3+/Tm3+ 上转换 纳米粒子 生物成像 |
| 收稿时间： | 2018-01-04 |
Synthesis of NIR-to-NIR Mn2+ Doped-NaYF4: Yb3+/Tm3+ Nanoparticles and Their Applications in Bioimaging |
| |
| LUO Yang,LIAO Zheng-fang,ZHANG Wei,ZUO Fang.Synthesis of NIR-to-NIR Mn2+ Doped-NaYF4: Yb3+/Tm3+ Nanoparticles and Their Applications in Bioimaging[J].Chinese Journal of Luminescence,2018,39(10):1371-1377. |
| |
| Authors: | LUO Yang LIAO Zheng-fang ZHANG Wei ZUO Fang |
| |
| Institution: | School of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041, China |
| |
| Abstract: | Mn2+ doped-NaYF4:Yb3+/Tm3+ upconversion fluorescence nanoparticles(NPs) were synthesized by one-step hydrothermal method under 200℃ for 8 h, and then the hydrophobic nanoparticles were transferred into water through coating amphiphilic polymer C18PMH-mPEG. Upconversion fluorescence emission spectrum of Mn2+ doped-NaYF4:Yb3+/Tm3+ NPs was measured under excitation by a near-infrared(NIR) light at 980 nm. The results of cytotoxicity test show that the water-soluble Mn2+ doped-NaYF4:Yb3+/Tm3+ NPs have good biocompatibility. Moreover, the prepared Mn2+ doped-NaYF4:Yb3+/Tm3+ NPs are used for in mice NIR imaging, which shows that it will have a certain application prospect in bioimaging. |
| |
| Keywords: | hydrothermal Yb3+/Tm3+ upconversion nanoparticles bioimaging |
|
| 点击此处可从《发光学报》浏览原始摘要信息 |
| 点击此处可从《发光学报》下载免费的PDF全文 |
