Highly Z/E stereoselective approach to β-iodo aza Morita-Baylis-Hillman adducts |
| |
Authors: | Cody Timmons |
| |
Institution: | Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA |
| |
Abstract: | A multicomponent reaction between sulfonyl-protected imines, magnesium iodide, and acetylenic esters or ketones is described. The resulting β-iodo aza Morita-Baylis-Hillman adducts were obtained in good yields and excellent Z/E stereoselectivities. The reaction showed good tolerance for sulfonyl protecting groups, as well as for acetylenic ketones and esters. This work presents the first synthetic approach to β-iodo aza Morita-Baylis-Hillman adducts. |
| |
Keywords: | Morita-Baylis-Hillman adducts Multicomponent reactions Magnesium iodide Imines |
本文献已被 ScienceDirect 等数据库收录! |
|