Radical trifluoromethylation of ketone Li enolates |
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| Authors: | Yoshimitsu Itoh |
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| Institution: | Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2-12-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan |
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| Abstract: | It has generally been believed that highly basic Li enolates cannot be applied as substrates for radical trifluoromethylation due to defluorination of the α-CF3 product. However, Li enolates can be in fact employed for radical trifluoromethylation. Moreover, the reaction is extremely fast and the minimum reaction time is only ∼1 s. |
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| Keywords: | Trifluoromethylation Li enolate Radical addition |
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