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Palladium-catalyzed carbonylative cyclization of Baylis-Hillman adducts. An efficient approach for the stereoselective synthesis of 3-alkenyl phthalides |
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| Authors: | Fernando Coelho Demetrius Veronese Vanderlei I. de Paula |
| Affiliation: | a Laboratory of Synthesis of Natural Products and Drugs, IQ/DQO, PO Box 6154, 13084-971 Campinas, SP, Brazil b IQ/DQI, UNICAMP, PO Box 6154, 13084-971 Campinas, SP, Brazil |
| Abstract: | A palladium-mediated carbonylative cyclization reaction of Baylis-Hillman adducts is disclosed. This simple, efficient and straightforward sequence leads to the formation of an array of 3-alkenylphthalides with different substitution patterns on the aromatic ring, with good chemical yields and selectivities. |
| Keywords: | Baylis-Hillman adducts Phthalides Cyclization Palladium |
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