Convenient synthesis of highly optically active 2,3,4,6-tetrasubstituted tetrahydropyrans via Prins cyclization reaction (PCR) of optically active homoallylic alcohols with aldehydes期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Convenient synthesis of highly optically active 2,3,4,6-tetrasubstituted tetrahydropyrans via Prins cyclization reaction (PCR) of optically active homoallylic alcohols with aldehydes

Authors:	Kazuhide Kataoka

Affiliation:	Department of Applied Chemistry, Okayama University of Science, 1-1 Ridai-cho, Okayama 700-0005, Japan

Abstract:	Prins cyclization reaction (PCR) of optically active homoallylic alcohols, R^aC^*H(OH)CH₂CHCHCH₃ (1-substituted but-2-en-1-ol), with aldehydes (R^bCHO) in the presence of an acid-catalyst (HX) affords (2-R^b,3-CH₃,4-X,6-R^a)-tetrasubstituted tetrahydropyrans highly stereoselectively in good yields.

Keywords:	Prins cyclization reaction Enantiomeric excess Nucleophile
本文献已被 ScienceDirect 等数据库收录！