Palladium-catalyzed C-N bond formation: synthesis of 1-aryl-1H-pyrazoles from β-bromovinyl aldehydes and arylhydrazines |
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| Authors: | Chan Sik Cho Daksha B Patel |
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| Institution: | a Research Institute of Industrial Technology, Kyungpook National University, Daegu 702-701, South Korea
b Department of Applied Chemistry, Kyungpook National University, Daegu 702-701, South Korea |
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| Abstract: | Cyclic and acyclic β-bromovinyl aldehydes are cyclized with an array of arylhydrazines in toluene at 125 °C in the presence of a palladium catalyst and a phosphorus chelating ligand together with NaOtBu to give 1-aryl-1H-pyrazoles in moderate to good yields. |
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| Keywords: | β-Bromovinyl aldehydes C-N bond formation Arylhydrazines Palladium catalyst Pyrazoles |
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