C-4′ Truncated carbocyclic formycin derivatives |
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Authors: | Jian Zhou |
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Institution: | Department of Chemistry and Biochemistry, College of Science and Mathematics, Auburn University, Auburn, AL 36849-5319, USA |
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Abstract: | Formycin is a naturally occurring C-glycoside (C-nucleoside) that possesses antitumor, antibacterial, antifungal, and antiviral activity. In connection with our ongoing interest in the design and syntheses of C-nucleoside derived antiviral agents this report describes the preparation of carbocyclic formycin and its 7-hydroxy (oxo) analog lacking the C-4′ hydroxylmethylene moiety in racemic form (4 and 6, respectively). An antiviral analysis of (±)-4 did not disclose any activity. |
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Keywords: | Formycin Carbocyclic C-nucleosides Epoxide ring opening Antiviral testing |
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