New stabilising groups for lateral lithiation of ortho-cresol derivatives |
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| Authors: | James A. Wilkinson Eun-Ang Raiber Sylvie Ducki |
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| Affiliation: | Centre for Molecular Drug Design, Biosciences Research Institute, Cockcroft Building, University of Salford, Salford M5 4WT, UK |
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| Abstract: | 1-(2-Methoxyethoxy)-2-methylbenzene and 1-(2-dimethylaminoethoxy)-2-methylbenzene have been lithiated using sec-BuLi under a variety of conditions and the laterally lithiated species trapped with electrophiles. |
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| Keywords: | Lateral lithiation Alkylation Cresol |
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