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Extraction of linear furocoumarins from Ammi Majus seeds by means of supercritical fluid extraction and supercritical fluid chromatography
Authors:O. I. Pokrovskii  A. A. Markoliya  F. D. Lepeshkin  I. V. Kuvykin  O. O. Parenago  S. A. Gonchukov
Affiliation:(1) Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, People’s Republic of China;(2) Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, People’s Republic of China;
Abstract:
A method of supercritical fluid extraction of the main furocoumarins (bergapten, xanthotoxin, and isopimpinellin, compounds used as photosensitizers in PUVA therapy) from seeds of apiaceous plant Ammi Majus was developed. A technique for analyzing the composition of extracts and for isolating individual furocoumarins with the help of supercritical fluid chromatography was proposed.
Keywords:
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