First organocatalyzed asymmetric Michael addition of aldehydes to vinyl sulfones |
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| Authors: | Mossé Sarah Alexakis Alexandre |
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| Institution: | Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet 30, CH-1211 Geneva, Switzerland. |
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| Abstract: | reaction: see text] The first asymmetric direct Michael addition of aldehydes to vinyl sulfones catalyzed by N-iPr-2,2'-bipyrrolidine is described. 1,4-Adducts are obtained in good yields and enantioselectivities. The determination of absolute configuration allowed us to postulate a Si,Si transition state model, as shown previously for nitroolefins. |
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