Activation profiles of opioid ligands in HEK cells expressing δ opioid receptors |
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| Authors: | Parham Gharagozlou Hasan Demirci J David Clark Jelveh Lameh |
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| Institution: | (1) Molecular Research Institute, 94043 Mountain View, CA, USA;(2) VA Palo Alto Health Care System, Palo Alto, CA, USA |
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| Abstract: | Background The aim of the present study was to characterize the activation profiles of 15 opioid ligands in transfected human embryonic
kidney cells expressing only δ opioid receptors. Activation profiles of most of these ligands at δ opioid receptors had not
been previously characterized in vitro. Receptor activation was assessed by measuring the inhibition of forskolin-stimulated cAMP production. |
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