Macathiohydantoin L,a Novel Thiohydantoin Bearing a Thioxohexahydroimidazo [1,5-a] Pyridine Moiety from Maca (Lepidium meyenii Walp.) |
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| Authors: | Ranran Zhang Junhong Liu Hui Yan Xingrong Peng Ling Zhang Minghua Qiu |
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| Institution: | 1.State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; (R.Z.); (J.L.); (H.Y.); (X.P.); (L.Z.);2.University of the Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Five new thiohydantoin derivatives (1–5) were isolated from the rhizomes of Lepidium meyenii Walp. NMR (1H and 13C NMR, 1H−1H COSY, HSQC, and HMBC), HRESIMS, and ECD were employed for the structure elucidation of new compounds. Significantly, the structure of compound 1 was the first example of thiohydantoins with thioxohexahydroimidazo 1,5-a] pyridine moiety. Additionally, compounds 2 and 3 possess rare disulfide bonds. Except for compound 4, all isolates were assessed for neuroprotective activities in corticosterone (CORT)-stimulated PC12 cell damage. Among them, compound (−)-3 exhibited moderate neuroprotective activity (cell viability: 68.63%, 20 μM) compared to the positive control desipramine (DIM) (cell viability: 88.49%, 10 μM). |
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| Keywords: | Lepidium meyenii thiohydantoins thioxohexahydroimidazo [1 5-a] pyridine neuroprotective activities |
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