The Pictet-Spengler reaction in the synthesis of condensed benzodiazepines 1. synthesis of 6,11,12,14-tetrahydrobenzo-[4,5][1,2]diazepino[7,1-b]quinazolin-14-ones |
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| Authors: | A S Tolkunov A I Khizhan S L Bogza |
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| Institution: | (1) L. M. Litvinenko Institute of Physical-Organic and Coal Chemistry, Ukraine National Academy of Sciences, Donetsk, 83114, Ukraine |
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| Abstract: | A new strategy is proposed for the synthesis of the seven-membered heterocyclic skeleton of tetrahydro4,5]1,2]diazepino7,1-b]quinazolin-14-ones
based on the Pictet-Spengler reaction of 3-amino-2-(3,4-dimethoxybenzyl)quinazolin-4(3H)-one with aromatic aldehydes and paraform
in acid media. |
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