Abstract: | We report the condensation of substituted 2-aminopyridines 5 with β-ketocarboxylic esters in polyphosphoric acid. In this reaction were obtained together with the target compounds, 4H-pyrido[1,2-a]pyrirnidin-4-ones 6 also the pyridin-2-ones 7 . All the compounds 7 were tested for their calcium-antagonistic activity but failed to evoke any vasorelaxant response. |