凝胶渗透色谱柱填料研究现状

凝胶渗透色谱法(GPC)是19世纪60年代开发的一种分离技术，作为一种液相分离色谱,其具有对流动相的要求不高、实验条件温和、重现性好、分析速度快、溶质回收率高等优点。这些优点使凝胶渗透色谱具有独特的分离效果，因此得到迅速发展并广泛用于石油化工、生物医药、食品卫生、环境监控等领域。该文对凝胶渗透色谱柱填料(如聚丙烯酰胺凝胶、聚苯乙烯凝胶等)的合成、性能以及应用进行综述，并对近年来出现的新型柱填料进行简要介绍。

Research on Status of Column Fillers for Gel Permeation Chromatography

Gel permeation chromatography(GPC) is a separation technology developed in the 1960s,which has the advantages of low requirements for mobile phase,mild experimental conditions,high reproducibility,rapid analysis and high solute recovery,etc.As a kind of liquid separation chromatography,gel permeation chromatography has a unique separation effect,it has been rapidly developed and widely used in many fields such as petrochemical engineering,biomedicine,food hygiene,environmental monitoring,etc.Progresses in the synthesis,performance and application of column fillers for gel permeation chromatography such as polyacrylamide gel and polystyrene gel in recent years are reviewed in this article,and the new fillers,as well as their application fields and prospects are also introduced.