TUMOR DESTRUCTION IN PHOTODYNAMIC THERAPY |
| |
| Authors: | J Stuart Nelson L-H Liaw Michael W Berns |
| |
| Institution: | Departments of Developmental and Cell Biology, University of California, Irvine, 1002 Health Sciences Road East, Irvine, CA 92717, USA;Departments of Surgery, University of California, Irvine, 1002 Health Sciences Road East, Irvine, CA 92717, USA;Beckman Laser Institute and Medical Clinic, University of California, Irvine, 1002 Health Sciences Road East, Irvine, CA 92717, USA |
| |
| Abstract: | Abstract The effects of photodynamic therapy (PDT) on the tumor microvasculature in the first few hours after treatment was studied at the light microscope (LM) and electron microscope (EM) levels in DBA/2Ha mice bearing SMT-F tumors. Animals received intraperitoneal injections of 10 mg kg− of Photofrin II and 24 h later tumors were treated with 100 J cm−2 of light (630 nm). Animals were sacrificed and their tumors removed at time 0, 30 min, 1, 2, 4, 8, 16 and 24 h after treatment. The results indicate that the effects of PDT are initially direct destruction of the microfibrils in the subendothelial zone of the tumor capillaries with subsequent tumor cell death secondary to hemorrhage and vascular collapse. |
| |
| Keywords: | |
|
|
