Synthesis of quinoxalines fused with triterpenes,ursolic acid and betulin derivatives期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Synthesis of quinoxalines fused with triterpenes,ursolic acid and betulin derivatives

Authors:	Korovin A. V. Tkachev A. V.

Affiliation:	(1) Department of Natural Sciences, Novosibirsk State University, 3a ul. Instituskaya, 630090 Novosibirsk, Russian Federation;(2) N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent"eva, 630090 Novosibirsk, Russian Federation

Abstract:	Oxidation of triterpenoids methyl ursonate, acetylbetulone, and allobetulone with atmospheric oxygen in the presence of Bu^tOK in Bu^tOH afforded the corresponding 2,3-diketo derivatives in 90-97% yields. These derivatives exist predominantly as tautomers containing the enolized keto group at the C(2) atom. Their reactions with o-phenylenediamine gave rise to the corresponding quinoxalines in 85-95% yields.

Keywords:	triterpenoids ursolic acid betulin allobetulin quinoxaline pyrazine ¹H and ¹³C NMR spectroscopy oxidation molecular oxygen /content/n1416t6304u23563/xxlarge945.gif" alt=" agr" align=" BASELINE" BORDER=" 0" >-diketones o-phenylenediamine
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