丁香酸-铜配合物的合成、表征及与DNA的相互作用的研究

自发现铂类配合物具有一定抗癌效果以来,小分子与金属离子配位的研究成为发现抗癌药物的重要途径。本文首先通过紫外光谱分析、红外光谱分析、质谱分析等方法证实丁香酸与铜离子形成配合物,且初步推断出配合物的组成为(C_9H_8O_5)Cu·H_2O;其次通过紫外光谱分析、荧光光谱分析、粘度测定等方法对丁香酸-铜配合物与DNA作用模式进行研究,证明了丁香酸-铜配合物与DNA作用模式为插入模式。

Synthesis, Characterization and Interaction of Ruthenic Acid - Copper Complexes with DNA

Since the discovery of platinum-like complex has a certain anti-cancer effect, the small molecule and metal ion coordination research has become an important way to find anti-cancer drugs. In this paper, the interaction between chlordecic acid and Cu_{2 +} complexes with DNA was studied to lay the theory foundation of synthesizing the higher quality succinic acid-copper complex, the life science experiment and the medical research of new drugs. In this experiment, the complexes of succinic acid and copper ion were studied by UV, IR and MS. The results showed that the composition of the complex was(C₉H₈O₅)Cu_.H₂O. Secondly, the model of the effect of succinic acid-copper complex on DNA was studied by UV, fluorescence and viscosity. It was proved that the combination of succinic acid-copper complex and DNA mode.