Addition of dithiols to bis-ynones: development of a versatile platform for the synthesis of polyketide natural products |
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Authors: | Sneddon Helen F Gaunt Matthew J Ley Steven V |
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Institution: | University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW. |
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Abstract: | reaction: see text] The conjugate addition of dithiols to bis-ynones generates a versatile masked 1,3,5-triketone platform. These functional units are useful intermediates for the synthesis of oxygen-containing heterocycles commonly found in polyketide natural products. The tetrahydropyranyl fragments of the marine macrolides Lyngbouilloside and Callipeltoside A have been synthesized with use of this methodology. |
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