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Synthesis and anticancer activity of some new pyridine derivatives |
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| Authors: | Fatma A. Bassyouni Hanaa A. Tawfik Abdel Mohsen Soliman Mohamed Abdel Rehim |
| Affiliation: | 1. Departments of Chemistry of Natural and Microbial Products and Pharmaceutical Research, Center of Excellence for Advanced Sciences, National Research Centre, Dokki, Cairo, 12622, Egypt 2. Department of Chemistry of Natural and Microbial Products, National Research Centre, Dokki, Cairo, 12622, Egypt 3. Department of Therapeutic Chemistry, National Research Centre, Dokki, Cairo, 12622, Egypt 4. Department of Clinical Pharmacology & DMPK, AstraZeneca, R&D, Sodertalje, 15185, Sodertalje, Sweden |
| Abstract: | Different substituents were introduced in positions 2 and 6 of 2,6 diaminopyridine in order to obtain new heterocyclic compounds. A new series of aza pyridine, imidazopyridine, benzodiazepine, indole, pyrimidine, and benzimidazole heterocyclic derivatives were synthesized in good yields. The anticancer activities of some of the new compounds were evaluated against liver cancer cell line HEPG2. Compounds 3, 4, 10, 11, 12, and 17 showed the highest activity when compared to 5-flurouracil (5-FU) and doxorubicin (DOX) chemotherapy. |
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