| 二盐酸氟哌噻吨几何异构体的核磁共振研究 |
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| 引用本文： | 郑艳萍,沈莉,孙秀燕,关玉昆.二盐酸氟哌噻吨几何异构体的核磁共振研究[J].分析试验室,2006,25(8):50-53. |
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| 作者姓名： | 郑艳萍 沈莉 孙秀燕 关玉昆 |
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| 作者单位： | 1. 烟台大学药学院,烟台,264005
2. 山东绿叶制药有限公司,烟台,264003 |
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| 摘 要： | 采用COSY、NOESY、HSQC、HMBC二维核磁共振技术，首次对二盐酸氟哌噻吨的两种几何异构体的^1H-NMR、^13C-NMR谱信号进行全归属。归属结果表明，二盐酸氟哌噻吨两种几何异构体的部分^1H-NMR、^13C-NMR谱数据差别较大，可作为区分两种异构体的一个指标。
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| 关 键 词： | 二盐酸氟哌噻吨 几何异构体核磁共振 NMR信号归属 |
| 文章编号： | 1000-0720（2006）08-050-04 |
| 收稿时间： | 11 29 2005 12:00AM |
| 修稿时间： | 2005-11-292005-12-26 |
NMR data assignments of two isomers of flupenthixol |
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| ZHENG Yan-ping,SHEN Li,SUN Xiu-yan,GUAN Yu-kun.NMR data assignments of two isomers of flupenthixol[J].Chinese Journal of Analysis Laboratory,2006,25(8):50-53. |
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| Authors: | ZHENG Yan-ping SHEN Li SUN Xiu-yan GUAN Yu-kun |
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| Institution: | 1. Medicial Institute, Yantai University, Yantai 264005 ; 2. Shandong Luye Pharmaceutical CO., LTD, Yantai 264003 |
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| Abstract: | A method for the assignments of all the()~1H-NMR and()~(13)C-NMR signals of the two isomers of flupenthixol dihydrochloride by()~1H-NMR,()~(13)C-NMR and two-dimensional NMR(COSY,HSQC,HMBC and NOESY) spectra of the isomers were proposed.The assignment indicate that there are some obvious differences between the isomers in()~1H-NMR and()~(13)C-NMR data. |
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| Keywords: | Flupenthixol NMR of isomers Signal assignment |
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