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Hesseltins B-G, novel meroterpenoids from a new Penicillium species |
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| Authors: | Richard K PhippsCharlotte H Gotfredsen Søren R PaludanJens C Frisvad Kathrine EriksenBent O Petersen Jens Ø DuusThomas O Larsen |
| Institution: | a Center for Microbial Biotechnology, Department of Systems Biology, 2800 Kgs. Lyngby, Denmark b Department of Chemistry, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark c Department of Medicinal Microbiology and Immunology, Wilhelm Meyers Allé 4, 8000 Århus C, Denmark d Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Valby, Denmark |
| Abstract: | Six new meroterpenoid compounds, hesseltins B-G, were isolated from Penicillium species along with the previously described hesseltin A. A further 14 compounds, which turned out to be photoisomers, were detected during purification and were subsequently isolated. The structures of these analogues were elucidated by comparison of their NMR spectral data with that of hesseltin A. None of the new hesseltins showed antiviral activity in a Herpes simplex virus type 2 assay. |
| Keywords: | Photoisomerism Penicillium Meroterpenoid Antiviral Hesseltin |
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