Toward cocaine esterase therapeutics |
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| Authors: | Rogers Claude J Mee Jenny M Kaufmann Gunnar F Dickerson Tobin J Janda Kim D |
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| Affiliation: | The Skaggs Institute for Chemical Biology and Departments of Chemistry and Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. |
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| Abstract: | ![]()
Cocaine is among the most reinforcing of all drugs of abuse, yet no effective pharmacotherapy is available. Herein, we report the development and characterization of phage-displayed cocaine esterases with pharmacologically relevant kinetic parameters (kcat/Km approximately 104 M-1 s-1). |
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