首页 | 本学科首页   官方微博 | 高级检索  
     


Chiral conformations induced by cyclodextrin
Authors:G. Le Bas  C. de Rango  N. Rysanek  G. Tsoucaris
Affiliation:(1) Laboratoire de Physique Centre Pharmaceutique, Université de Paris-Sud, 92290 Chatenay-Malabry, France
Abstract:
Studies of chiroptical properties need separation or at least enrichment of enantiomers. The separation is difficult with chiral conformers of molecules with very low barriers of internal rotation. However, in association with cyclodextrin, these labile molecules can exhibit a strong Cotton effect in solution: one chiral conformer is favoured by complexation. The cyclodextrins have the advantage to yield inclusion complex in solution as well as crystalline clathrates. Therefore, the absolute configuration of the guest can be obtained by determining the structure of the cyclodextrin. In this work, the first CD spectrum of 4-helicene is recorded and crystal structures of several clathrates of labile molecules are studied.
Keywords:
本文献已被 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号